N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

AASraw se ak sentèz ak kapasite pwodiksyon soti nan gram bay lòd mas nan N-phenyl-4- (3-Phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-karboksamid poud (CAS 681136-29-8), anba CGMP règleman ak sistèm kontwole bon jan kalite.

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid powder se yon piperazilin phenyl urea ki gen estrikti diferan de carbam alkyl ak alfat keto heterocyclic konpoze epi li se yon inhibitor ki pisan ak selektif nan asid gra amid idilaz (FAAH) (IC50s = 34 ak nnmnx nan rat ak moun, respektivman) ki se kapab pou travèse baryè san an nan sèvo a.33 Nan 1 mg / kg, kovalent mare nan sit la aktif nan FAAH nan klivaj nan fonctionnalités a urea générer anilin ak yon carbamate FAAH-poperazinyl.

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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide video


I.N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide basic Characters:

Non: N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
Sèrtifikasyon: 681136-29-8
Pite: ≥99 (HPLC)
Sinonim: JNJ 1661010;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide;Takeda-25;1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-;JNJ 1661010, >=98%
Molekilè Fòmil: C19H19N5OS
Molekilè Pwa: 365.459
Pwen fonn: 240.48
Bouyi pwen: 559.69 ° C nan 760 mmHg
Dansite: ~ 1.3 g / cm3
Tanp Depo: Sere nan + 4 ° C
Solisyon: DMSO: ≥28mg / mL
Endèks refractif: n20D 1.68
Koulè: Yon solid cristalline
InChI: InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
Inch kle: BHBOSTKQCZEAJM-UHFFFAOYSA-N


II. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) Piperazine-1-karboksamid Powder l 'nan sik:

1.Name:

N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-karboksamid poud, JNJ 166101 Powder

2.How se travay la sou N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Powder l '?

FAAH preincubated ak JNJ-1661010 sijere yon reversibilite ralanti nan entèraksyon an ant JNJ1661010 a ak sit la aktif, ki se akselere nan pi wo tanperati. JNJ-1661010 se yon covalent, mekanik ki baze sou inhibite substra kòm egzamine pa LC-ESI-MS. JNJ-1661010 waf ak phenylthiadiazol la nan tinèl la idrofob ak phenylurea a nan pòch idrofil la nan FAAH, JNJ-1661010 (20 mg / kg IP) inibit FAAH pa omwen 85 pou jiska 4 h apre yo fin dòz, ki kapab lakòz akimilasyon nan lipid etanolamid nan sèvo rat. JNJ-1661010 dòz-depannman ranvèse allodynia la touche ak yon efikasite maksimòm de apeprè 90 nan Postdose minne XNUM nan tou de ti modèl blesi tiseu (MTI) ak modèl rat. JNJ-30 (1661010 mg / kg) ranvèse allodynia touche pa 20 nan min 60.8 nan rat modèl nè ligasyon nè rat. JNJ-30 (1661010 mg / kg IP) montre yon siyifikatif atenuasyon nan hyperalgesia a nan 50 postdoz min nan modèl rat carrageenan nan doulè enflamatwa.
Rat dosed ak JNJ-1661010 (20 mg / kg ip) gen yon Cmax plasma nan 26.9 μM nan Tmax la nan 0.75 h ak yon Cmax nan sèvo a nan 6.04 μM nan Tmax la nan 2 h. JNJ-1661010 (20 mg / kg IP) inibit FAAH nan sèvo ak elve AEA nivo nan tisi nan sèvo nan rat.

3.Warning sou N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-karboksamid poud

4.Pli plis enstriksyon:

5. N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid Powder:

Min lòd 10grams.
Ka ankèt la sou kantite nòmal (Nan 1kg) yo ka voye nan èdtan 12 apre peman.
Pou pi gwo lòd (Nan 1kg) yo ka voye soti nan kandida 3 apre peman.

6. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Powder Recipes:

Pou ankèt Reprezantan Kliyan nou an (CSR) pou detay, pou referans ou.

7. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-karboksamid poud Maketing:

Yo dwe bay nan lavni kap vini an.


III. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid poud HNMR

Nou se Aprepitant poud supplémentaires, Aprepitant poud pou vann, poud Aparitant poud (170729-80-3) hplc ≥98 | AASraw R & D Reyaktif


IV. Ki jan yo achte N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-karboksamid poud ki soti nan AASraw?

1.To kontakte nou pa imèl nou ansistèm rechèch, oswa sou entènèt skypereprezantan sèvis kliyan (CSR).
2.To ban nou kantite lajan ou mande ak adrès.
CSNUMX.Our CSR ap ofri ou sitasyon pi ba, tèm peman, nimewo swiv, fason livrezon ak estime arive dat (ETA).
4.Payman fè ak byen yo pral voye soti nan èdtan 12 (Pou lòd nan 10kg).
5.Goods resevwa epi bay kòmantè.


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